Product Details
Name: Tranexamic Acid
CAS NO. :1197-18-8
Description: White Crystalline Powder
Chemical name: p-aminomethylcyclohexanecarboxylic acid, trans-4-aminomethyl-cyclohexanecarboxylic acid.
English name: trans-4-(Aminomethyl) cyclohexanecarboxyli c acid
CAS RN: 1197-18-8
EINECS number: 214-818-2
Molecular formula: C8H15NO2
Molecular weight: 157.21
Purity: ≥99.0%
Density: 1.096g/cm3
Melting point: 300ºC
Boiling point: 300.201°C at 760 mmHg
Flash point: 135.357°C
Physical and chemical properties: white crystalline powder.Odorless.The taste is slightly bitter.
Medicinal use of tranexamic acid raw materials:
Effect: Tranexamic acid can be strongly adsorbed with the lysine binding site (LBS) of the fibrin affinity site on plasmin and plasminogen, which inhibits the binding of plasmin, plasminogen and fibrin, thereby strongly inhibiting the breakdown of fibrin caused by plasmin; In addition, in the presence of anti-plasminases such as macroglobulin in serum, the anti-fibrinolytic effect of tranexamic acid is more obvious!!!
Clinical use
Folding trauma
Studies have shown that tranexamic acid can safely and reliably reduce the mortality rate of patients with traumatic bleeding.In view of this, tranexamic acid, a cheap, non-patented drug, has been included in the WHO list of essential medicines and will be widely used in high-, middle- and low-income countries around the world.
Folding craniocerebral trauma
Studies have shown that craniocerebral patients receiving tranexamic acid are less likely to develop progressive bleeding, and the mortality rate also tends to decrease.
Although neither of these two studies came to very clear conclusions, they still suggested that tranexamic acid may improve the prognosis of traumatic brain injury. This will lay the foundation for follow-up studies, such as the upcoming CRASH-3 study that will recruit up to 10,000 patients with craniocerebral injury. It will provide reliable evidence for the efficacy of tranexamic acid in improving mortality and disability rates.
Fold too much menstrual blood
Tranexamic acid can significantly reduce blood loss in women with excessive menstrual blood.A Cochrane systematic review evaluating anti-fibrinolytic drugs (mainly tranexamic acid) for the treatment of menstrual hyperemia pointed out that compared with placebo or other treatments, anti-fibrinolytic preparations can reduce blood loss in women with menorrhagia more, without increasing the incidence of side effects.The U.S. Food and Drug Administration approved tranexamic acid oral tablets as a treatment measure for women with severe menstrual hyperemia on November 13, 2009.
Folding postpartum bleeding
Studies have shown that tranexamic acid significantly reduces postpartum bleeding.However, due to the slightly lower methodological quality of the three randomized trials included, there is currently no evidence from high-quality studies to support the application of anti-fibrinolytic drugs in postpartum bleeding.Currently, a randomized double-blind placebo-controlled trial called WOMAN (The World Maternal Antifibrinolytic Trial) is under way. It will recruit 15,000 patients worldwide to provide reliable evidence for the early application of tranexamic acid to improve the mortality rate and hysterectomy rate of patients with postpartum bleeding.
Folding surgery
A Cochrane systematic evaluation of 65 randomized controlled trials pointed out that tranexamic acid reduced the risk of postoperative blood transfusion by nearly 1/3 (RR 0.61, 95% CI 0.53 to 0.70) and reduced the amount of bleeding during and after the operation. At the same time, the incidence of thromboembolic events did not increase.
No other therapeutic effects
Tranexamic acid is also used as a second-line regimen for adjuvant treatment before and after surgery in hemophilia patients with factor deficiency.And it can also be used for hereditary angioedema.
Folding whitening effect
Its blackening and spot removal effect is about 50 times higher than that of vitamin C, and it is nearly 10 times that of fruit acid.
Package
Packing: Barrel
NW: 25KG
GW: 27.5KG
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